Cardarine (GW501516)
PPAR Delta Agonist
£50.00
What’s Included
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60 capsules per bottle -
10mg pure GW501516 per capsule
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2-month supply (1 cap daily)
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Third-party lab certificate included
Lab Tested
Third-party verified
Fast Shipping
3-7 business days
24/7 Support
Expert guidance
Product details
Buy Cardarine UK: CORE supplies Cardarine (GW501516) in the UK as 60 x 10mg capsules, third-party lab tested, with the certificate included. Cardarine GW501516 is a PPAR delta agonist studied for its effects on endurance and fat metabolism. Originally developed for treating metabolic disorders, it has become the ultimate supplement for athletes seeking enhanced performance and body composition.
Our pharmaceutical-grade Cardarine is produced under strict quality controls and third-party tested for purity. Each capsule contains 10mg of pure GW501516, providing consistent energy and fat-burning benefits.
A Different Class of Compound
Cardarine GW-501516 occupies a unique position in the research chemicals market. Unlike SARMs, which target androgen receptors, Cardarine activates PPARdelta, a nuclear receptor that regulates genes involved in fat metabolism, mitochondrial development, and oxidative muscle fibre expression.
The result is a compound with a completely different performance profile: less about muscle building, more about conditioning, endurance, and metabolic efficiency.
Potential Sports Benefits
Fat metabolism is the key to endurance. During high-intensity training, your body relies on fat oxidation for energy and replenishment. As a result, the better your body metabolises fat, the more carbs you save, effectively prolonging your physical activity.
Since Cardarine GW-501516 may boost fat metabolism, it may have the abovementioned effect, not only potentially helping you get a leaner build, but also boosting your performance in endurance sports.
Browse our full range of endurance and energy compounds.
Active Ingredients
Purity & Quality
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Third-party lab tested -
99.5%+ purity guaranteed -
24-month shelf life
Cardarine (GW501516) works by activating PPAR delta receptors, which regulate genes involved in fat oxidation and energy metabolism. This activation increases the body’s ability to burn fat for fuel while preserving muscle tissue.
The compound enhances mitochondrial function and promotes the development of slow-twitch muscle fibers, leading to dramatically improved endurance capacity. Users often report being able to perform longer, more intense workouts without fatigue.
With a half-life of 16-24 hours, Cardarine provides sustained metabolic enhancement throughout the day, making it ideal for both training and recovery periods.
Key Actions
Endurance and Fat Oxidation
For researchers and athletes focused on fat loss and cardiovascular performance, Cardarine’s mechanism is well-documented.
A mouse study published in Scientific Reports found that GW501516 increased running endurance and promoted a shift toward oxidative muscle fibre expression, both with and without concurrent exercise training. [1]
By shifting the body’s primary fuel source toward fatty acids, it supports:
- Sustained high-intensity output.
- Reduced reliance on glycogen during training.
- Preservation of lean tissue through a caloric deficit.
- Improved recovery between sessions.
The endurance benefits are typically felt quickly, with peak performance effects becoming consistent by weeks two to three.
Cardiovascular and Metabolic Research
Cardarine has also been studied for its effects on lipid metabolism. The original characterisation of the compound, published in PNAS, examined its role in reverse cholesterol transport and HDL regulation, the mechanism that first drew clinical interest in metabolic disease research. [2]
This makes it a compound of continued relevance beyond performance contexts.
At 10mg daily, Cardarine delivers consistent results. Cycle lengths should not exceed 8-10 weeks. It does not interact with androgen receptors and does not require PCT. Cardarine is classified by WADA as an S4 metabolic modulator and is prohibited in competitive sport. Sold strictly for research purposes, with batch-specific certificates of analysis available for all stock.
Cardarine isn’t a SARM at all. It works through a different pathway that shifts how your body burns fuel, which is why it’s built for endurance rather than mass. Learn more in muscular endurance guide
Real results from real customers
Transformations from verified customers. Individual results vary.
Reviews
Rated 5 by verified UK buyers.
What are the Key Benefits of Cardarine (GW501516)?
Enhanced endurance
Accelerated fat loss
Improved recovery
Increased energy
Better cardiovascular health
Metabolic enhancement
Cardarine Dosage: How to Use Cardarine (GW501516)?
Dosage
10mg once daily
Timing
Take 30-45 minutes before workout
Cycle Length
8-12 weeks followed by a 4-week break
Important
Dietary supplement use only
Can be taken on empty stomach. Split dose if taking 20mg daily.
Training
Built for long cardio sessions, endurance events, and high-volume lifting.
Diet
Eat at maintenance or a deficit. Include plenty of fiber and skip heavily processed fats.
Stacking and cycle guidance
Cardarine complements a wide range of protocols thanks to its non-hormonal profile. Pick a single companion below to stack with Cardarine and save 5%, or choose a complete bundle further down for a bigger discount:
RAD 140 (Testolone) + Cardarine (GW501516)
Recomposition: RAD-140 builds muscle while Cardarine burns fat, hitting recomp from both sides.
£95.00 £100.00 Save 5%
Cardarine 5-10mg, 1-2 hours before training. RAD-140 5-15mg each morning. Run together for 8-10 weeks. PCT required for the RAD-140 portion.
RAD 140 dosage, side effects and results guide
Ostarine (MK2866) + Cardarine (GW501516)
Recomposition: Cardarine's fat-burning support pairs with Ostarine's muscle-preserving effect for a clean recomp.
£90.25 £95.00 Save 5%
Ostarine 15-20mg each morning. Cardarine 5-10mg, 1-2 hours before training. Run together for 8 weeks. PCT optional depending on Ostarine dose.
SR9009 (Stenabolic) + Cardarine (GW501516)
Endurance stack: SR-9009 stacks with Cardarine for a dual-pathway endurance boost, popular with runners and cyclists.
£90.25 £95.00 Save 5%
Cardarine 5-10mg, 1-2 hours before training. SR-9009 10-20mg, split into 2-3 daily doses. Run together for 8 weeks. No PCT required for either compound.
Complete Bundles
Prefer a full protocol in one order? These pre-built bundles pair Cardarine (GW-501516) with 3-4 companions at a bigger combined discount:
Cutting Bundle
Complete stack: RAD-140, Ostarine, and Cardarine bundled into a complete cutting protocol, priced below buying each alone.
£130.00 £145.00 Save 10%
RAD-140 and Ostarine (10mg each) together each morning; Cardarine 10mg 1-2 hours before training. 6-8 weeks max. PCT required for the RAD-140 portion.
The CORE SARMS Handbook walks through dosing, cycle length, and stacking logic for every compound on this page.
Read the CORE SARMs Handbook →Post-cycle support
Frequently Asked Questions
Contact supportCardarine is a PPAR delta agonist that enhances endurance, promotes fat loss, and improves overall metabolic function.
Most users experience enhanced endurance within 1-3 days of starting Cardarine supplementation.
Yes, Cardarine is excellent for cutting phases as it promotes fat loss while preserving muscle mass and maintaining energy levels.
Read our guide to the ultimate cutting stack featuring Cardarine.
Cardarine is generally well-tolerated at recommended doses. Mild effects may include headaches, nausea, or changes in liver enzyme levels. High or prolonged doses have shown potential risks in animal studies, so adherence to dosing guidelines is important.
Follow recommended cycle lengths and take breaks between cycles. Consult healthcare providers for long-term supplementation plans.
Yes, Cardarine stacks well with SARMs and other supplements. It’s particularly effective when combined with muscle-building compounds.
GW501516, commonly known as Cardarine, is a PPAR receptor agonist that enhances the body’s ability to burn fat and improve endurance. It supports better energy metabolism, stamina, and cardiovascular performance, making it ideal for athletes focused on fat loss, endurance, and conditioning.
Most users experience increased endurance and energy within 1-2 weeks of consistent use. Noticeable fat-loss and performance improvements are typically seen after 3-4 weeks, depending on training intensity and diet.
Cardarine does not directly build muscle like SARMs, but it helps preserve lean muscle mass during calorie deficits. Its ability to improve recovery and stamina supports longer, more effective training sessions, which can indirectly promote lean muscle development.
For best results, Cardarine is often taken 30-45 minutes before a workout to maximize endurance and performance. On non-training days, it can be taken at any consistent time to maintain steady levels in the system.
To enhance performance with Cardarine GW501516, athletes usually take 10-20 mg per day. [3] This means 1-2 capsules daily. If you take 2 capsules per day, be sure to split the dose.
According to multiple research studies, Cardarine is metabolised in your system in fewer than 5 days. However, higher concentrations of its metabolites can be found in your system for longer periods of time. [4][5]
You can buy Cardarine UK directly from CORE. Each bottle holds 60 x 10mg Cardarine (GW501516) capsules, a 2-month supply at 1 capsule daily, with a third-party lab certificate included. UK orders typically arrive in 3-7 business days.
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Sources:
[1] Chen, W., Gao, R., Xie, X., et al. (2015). A metabolomic study of the PPARdelta agonist GW501516 for enhancing running endurance in Kunming mice. Scientific Reports, 5, 9884. https://doi.org/10.1038/srep09884
[2] Oliver, W. R., Shenk, J. L., Snaith, M. R., et al. (2001). A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. PNAS, 98(9), 5306-5311. https://doi.org/10.1073/pnas.091021198
[3] Kintz, P., Ameline, A., Gheddar, L., & Raul, J. S. (2020). Testing for GW501516 (cardarine) in human hair using LC/MS-MS and confirmation by LC/HRMS. Drug testing and analysis, 12(7), 980–986. https://doi.org/10.1002/dta.2802
[4] Sobolevsky T., Dikunets M., Sukhanova I., Virus E., Rodchenkov G. Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine. Drug Test. Anal. 2012;4:754–760. doi: 10.1002/dta.1413.
[5] Thevis M., Möller I., Beuck S., Schänzer W. Synthesis, mass spectrometric characterization, and analysis of the PPARδ agonist GW1516 and its major human metabolites: Targets in sports drug testing. Methods Mol. Biol. 2013;952:301–312. doi: 10.1007/978-1-62703-155-4_22
